She has worked across several mediums including painting, linocut prints and batik, but her chosen medium is ceramics. For 20 years she worked out of the Ernabella Arts where she honed her craft before joining the APY Studio Adelaide in 2020. In 2012 she was a finalist in the Indigenous Ceramic Art Awards at Shepparton Art Museum.

Tjimpuna uses traditional patterns that relate to rockhole (tjukula) or sand dune (tali), and also paints the Tjukurpa of her mother’s Country Piltati, near Kanpi in the APY Lands. Tjimpuna's artwork has been included in exhibitions in Australia and overseas. Her artwork has been acquired for the collections of the National Museum of Australia, Australian National Gallery, Queensland Art Gallery and Museum of Ethnology, Osaka, Japan.